Dr. Mark D. Shen (University of North Carolina, Chapel Hill) discusses the trajectory of brain development in infants at risk for autism spectrum disorder (ASD) and fragile X syndrome. Longitudinal imaging was captured from 6 to 24 months to see how brain development differed between groups, and the development of the amygdala in infants at risk for ASD prior to onset of social deficits and clinical diagnosis.

Shen interview [01:03]
Why look at patients with potential ASD diagnosis in conjunction with fragile X syndrome patients? [04:20]
Why are differences in brain structure important? [05:46]
What’s the advantage of earlier diagnosis of ASD? [08:16]
What’s next for your research? [09:48]
Kalin interview [11:47]
Shen et al. [12:09]
Girault et al. [15:30]
Gerlach et al. [19:13]
Mosholder et al. [22:12]
Summary [25:31]

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August 2022: Subcortical Brain Development in Autism and Fragile X Syndrome

American Journal of Psychiatry Audio