Dr. Antonia Seligowski (McLean Hospital and Harvard Medical School) discusses how significant genetic correlations were identified between PTSD and cardiovascular disease as well as support for a causal link from PTSD to hypertension and coronary artery disease. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue and what draws it together.

Seligowski interview [00:50]
Genome-wide association studies [02:24]
The Mass General Brigham Biobank [03:05]
What were the limitations of the study? [04:05]
Are there current clinical implications? [05:04]
How does depression fit in? [06:11]
Are the links between PTSD and cardiovascular disease linked to associated comorbidities? [07:00]
What’s next for your research? [07:52]
Kalin interview [08:51]
Seligowski et al. [09:06]
Leone et al. [10:57]
Hindley et al. [13:50]
Lewis and Vassos [17:37]
Sigström et al. [18:13]
Brownstein et al. [20:32]
In summary [25:03]

Transcript

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November 2022: Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

American Journal of Psychiatry Audio