Dr. Peter Attia: Supplements for Longevity & Their Efficacy

The NAD pathway, including precursors like NR and NMN, lacks sufficient scientific evidence to justify its use for extending human lifespan. While NAD levels naturally decline with age, no robust data confirms that exogenous supplementation effectively reverses aging or improves healthspan in humans. The initial hypothesis linking sirtuin activation and caloric restriction to longevity has failed to replicate across rigorous Interventions Testing Program (ITP) studies. Instead, foundational behaviors—specifically consistent exercise, high-quality sleep, and disciplined nutrition—remain the most effective drivers of longevity. Dr. Peter Attia emphasizes that while molecules like rapamycin show promise in animal models, they are distinct from the commercialized NAD supplements that currently lack clinical significance. Ultimately, prioritizing behavioral health is the only proven strategy for delaying chronic disease and maintaining long-term vitality, rendering most longevity-focused supplements secondary to fundamental lifestyle choices.