This podcast episode delves into the recent mpox outbreak in Africa, following its declaration as a public health emergency by the WHO and the challenges it poses, particularly in the Democratic Republic of Congo (DRC). Professor Salim Abdool Karim discusses the emergence of new mpox clades with increased transmissibility and case fatality rates, underscoring the significance of global solidarity in vaccine access amidst ongoing crises. Despite the difficulties, he remains hopeful for a community-driven response and the Africa CDC's mobilization efforts to combat the outbreak and ensure long-term prevention strategies.