In this episode of The Metabolic Classroom, Dr. Ben Bikman explores the topic of leaky gut syndrome, explaining how substances enter the body through the intestines and how the gut acts as a controlled gateway.

While nutrients like amino acids, glucose, and fats are transported through the intestinal lining via a process called transcellular transport, problems arise when the tight junctions between the cells weaken. This can lead to harmful substances, including large molecules and microbes, passing into the bloodstream in a process known as paracellular transport.

A key player in leaky gut syndrome is the molecule lipopolysaccharide (LPS), which comes from certain gut bacteria. Under normal conditions, LPS stays in the intestines and is expelled with waste, but when it enters the bloodstream due to leaky gut, it can trigger a chronic inflammatory response. This inflammation is linked to conditions like obesity, heart disease, and fatty liver disease. Bikman emphasized that even low levels of LPS in the blood can promote insulin resistance, further contributing to metabolic disorders.

Several dietary and environmental factors can compromise the integrity of the gut barrier. Ben highlights the negative impact of fructose, which weakens tight junction proteins and promotes oxidative stress. Polyunsaturated fats from refined seed oils and gluten, especially in people with sensitivities, can also increase intestinal permeability. Additionally, chronic stress and alcohol consumption were identified as contributors to leaky gut.

On a positive note, Dr. Bikman discusses strategies to improve gut health, such as consuming short-chain fatty acids (like butyrate), found in dairy and certain fibers. He also mentioned the potential benefits of saturated fats, particularly from dairy, which may promote gut healing. Lastly, Dr. Bikman shares the role of LDL cholesterol as a “scavenger” that helps remove harmful LPS from the blood, suggesting its misunderstood importance in immune health.

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00:00 Introduction to Leaky Gut

01:52 How Substances Enter the Body Through the Gut

03:58 Structure and Function of the Gut Lining

07:07 Normal Transport vs. Leaky Gut Transport

09:23 The Role of LPS in Leaky Gut and Inflammation

11:41 How LPS Affects the Body

12:45 Low-Grade Systemic Inflammation

15:23 Cardiometabolic Consequences of Leaky Gut

18:52 Dietary Triggers of Leaky Gut: Fructose and Seed Oils

22:14 The Impact of Gluten and Stress on Gut Health

24:05 Strategies to Improve Gut Health

25:09 Short Chain Fatty Acids and Saturated Fats for Gut Healing

28:08 The Role of LDL Cholesterol in Gut Health

31:16 The Importance of Fiber and Probiotics

33:32 The Rare Sugar Allulose and Gut Integrity

35:23 Conclusion and Practical Takeaways

My favorite meal-replacement shake: https://gethlth.com (discount: BEN10)

My favorite electrolytes (and more): https://redmond.life (discount: BEN15)

My favorite allulose source: https://rxsugar.com (discount: BEN20)

Study references referred to are available upon request. Email: support@insuliniq.com

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Leaky Gut Explained: Dr. Ben Bikman on Gut Health and Inflammation

The Metabolic Classroom with Dr. Ben Bikman