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Michael Dickens has read the research and performed two self-experiments on whether consuming caffeine builds up tolerance, and if yes, how quickly.

First literature review:

What if instead of taking caffeine every day, you only take it intermittently—say, once every 3 days? How often can most people take caffeine without developing a tolerance?

The scientific literature on this question is sparse. Here's what I found:

Experiments on rats found that rats who took caffeine every other day did not develop a tolerance. There are no experiments on humans. There are no experiments that use other intermittent dosing frequencies (such as once every 3 days).
Internet forum users report that they can take caffeine on average once every 3 days without developing a tolerance. But there's a lot of variation between individuals.

Second literature review:

If you [...]

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First published:
September 4th, 2024

Source:
https://www.lesswrong.com/posts/3bmoxXgJpfcoZpmcJ/michael-dickens-caffeine-tolerance-research

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“Michael Dickens’ Caffeine Tolerance Research ” by niplav

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