This is a link post.

Note: This post is co-authored with Stacy Li, a PhD student at Berkeley studying aging biology! Highly appreciate all her help in writing, editing, and fact-checking my understanding!

Introduction

The last time I read about aging research deeply was around 2021. The general impression I was getting was that aging research was increasingly more and more funded (good!). Unfortunately, none of the money led to actionable or useful insights (bad).

Over time, you get slightly burnt out by all the negative news.

After getting a job in biotech, I kept a hazy eye on the subject but mostly tuned out of it entirely. But, especially today, I am curious: how has the aging field progressed in the last few years? Since 2021, what has changed?

In this post, I’ll share a list of immediate questions about the state of affairs in aging research, and the [...]

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Outline:

(00:31) Introduction

(01:30) Did the therapeutic focus on sirtuins amount to much?

(01:35) Background

(03:55) Answer

(05:48) Have the longevity-focused research institutions/grant programs/startups led to anything significant?

(05:56) Background

(07:37) Answer

(09:22) Has cellular reprogramming yielded anything useful?

(09:40) Background

(16:05) Answer

(20:24) What's the state of biological clocks?

(20:28) Background

(24:14) Answer

The original text contained 2 images which were described by AI.

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First published:
August 22nd, 2024

Source:
https://www.lesswrong.com/posts/dWAmkSqLE4YMQRuhj/a-primer-on-the-current-state-of-longevity-research

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Narrated by TYPE III AUDIO.

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“A primer on the current state of longevity research ” by Abhishaike Mahajan

LessWrong (30+ Karma)