#46 - Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease - NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine, and more

In this podcast episode, Peter Attia and Chris Masterjohn dive deep into the vital role of choline in our health, particularly its impact on non-alcoholic fatty liver disease (NAFLD) and heart health. Masterjohn highlights the need to consider the historical context of nutritional science while navigating dietary interventions. He discusses how choline can be both beneficial and harmful if taken in excess. By exploring choline's biochemical pathways, its link to methylation cycles, and the nuances of fatty acids, the episode sheds light on the complex relationship between diet, genetics, and overall well-being. It ultimately encourages listeners to approach supplementation and dietary decisions with care and thoughtfulness.