This podcast episode explores the role of fructose in metabolism, particularly its impact on high blood pressure, uric acid levels, and the development of metabolic diseases. Dr. Rick Johnson, a renowned professor of medicine and expert on fructose metabolism, discusses his research on the mechanisms causing kidney disease and the link between fructose and obesity, diabetes, and heart disease. The conversation also covers the controversial relationship between salt and high blood pressure, the evolutionary significance of fructose metabolism, and the promising advancements in pharmacotherapy for metabolic diseases.