As a follow up to AMA #14 where Peter explained his framework for analyzing labs, this “Ask Me Anything” (AMA) episode focuses on a number of real-world case studies exploring metabolic dysregulation, low testosterone, menopause, hypothyroidism, elevated uric acid, and more. From the examples discussed, you can follow along how our clinical team goes about interpreting diagnostic measures and applying relevant research findings. Once again, Bob Kaplan, Peter’s head of research, will be asking the questions. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #15 show notes page.

We discuss:

Should you stop taking supplements before getting a lab test? [2:45];
Family history—Questions to ask and what to look for [5:30];
The purpose of an oral glucose tolerance test (OGTT) [12:15];
Case study—Insufficient muscle mass for proper glucose disposal [17:15];
Why hemoglobin A1c is a relatively unhelpful metric [24:00];
Case study—Exceeding carbohydrate tolerance [26:30];
Case study—Metabolic dysfunction and a framework for metabolic health [33:30];
Peter’s ideal tracking of metabolic health for all his patients [43:30];
Contrasting presentations of hypogonadism—Low free testosterone [45:00];
How sleep, exercise, and alcohol affect testosterone levels? [56:20];
Case study—Surprisingly fast onset of menopause [59:25];
Case study—Hypothyroidism and high cholesterol [1:07:00];
Case study—Elevated uric acid and hypertension [1:10:55]; and
More.

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#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more

The Peter Attia Drive