This podcast episode delves into the science of longevity and exercise physiology with physician researcher Mike Joyner. The conversation emphasizes the benefits of exercise for living longer and its importance as we age. The impact of exercise on cardiovascular health, autonomic nervous system, and skeletal muscle blood flow regulation is explored. The significance of VO2 max in predicting mortality and countering the effects of aging is highlighted. The section also discusses training methods of elite athletes, the importance of active rest, and managing suffering during endurance events. The concept of maintaining form and tempo in sports is examined, along with the evolution of doping and the potential for exercise memetics as a pharmaceutical strategy. The section concludes by addressing the importance of increasing physical activity levels, particularly through the creation of accessible facilities and organized activities.