In this interview, Dr. Rangan Chatterjee and Speaker 2 discuss the importance of liver and visceral fat in determining health, rather than overall weight. The conversation covers the causes and consequences of different fat depots: subcutaneous, visceral, and liver fat, with a focus on how stress impacts visceral fat accumulation. They explore the role of the amygdala and the four "brakes" on it, which include prefrontal cortex reasoning, hippocampus memory, afferent vagus nerve function, and oxytocin levels. The discussion also covers the impact of ultra-processed foods, reactive oxygen species, and the role of antioxidants. They also discuss the utility of continuous glucose monitors, and the importance of individualized approaches to diet. The podcast concludes with a discussion on the definition of "real food" and the importance of avoiding ultra-processed foods for optimal health.
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