This podcast episode explores the concept of isolation and its psychological effects on individuals. It discusses various examples, including the movie Castaway, solitary confinement, and the experiences of Nelson Mandela. The conversation highlights the distinction between involuntary and voluntary solitude, emphasizing the importance of social interaction and sensory stimulation for human well-being. The episode also touches on the value of connection, choice, and agency in isolation. Overall, it sheds light on the detrimental effects of involuntary isolation and the subjective nature of being alone.