Dr. David Sinclair: The Biology of Slowing & Reversing Aging

Aging functions as a disease characterized by the loss of cellular information due to entropy, specifically within the epigenome. The epigenome acts as a reader for genetic information, and over time, "scratches"—such as DNA damage and chemical changes like methylation—disrupt this system, causing cells to lose their identity and function. Interventions to slow or reverse these effects include intermittent fasting, which triggers longevity genes like sirtuins and reduces mTOR activity, and the use of NAD precursors like NMN to fuel these cellular defenses. While growth hormone and high protein intake may provide immediate vitality, they often accelerate aging. Optimizing health requires monitoring biomarkers like C-reactive protein and insulin sensitivity, alongside lifestyle choices that induce biological stress, such as cold exposure and strategic fasting, to maintain youthful gene expression and cellular repair.