Longevity supplementation requires a critical distinction between subjective vitality and proven lifespan extension. Current evidence does not support the use of resveratrol, metformin, or rapamycin for extending human lifespan. While precursors like NR and NMN, along with direct NAD infusions, may enhance daily energy levels and physical vigor, they lack clinical validation as longevity agents. Supplements remain secondary to the foundational pillars of health: consistent, high-quality sleep, regular cardiovascular and resistance training, optimal nutrition, and stress modulation. These lifestyle interventions provide measurable improvements in health metrics that far exceed the benefits of any pharmacological or supplemental regimen. Prioritizing these basics, alongside professional medical consultation, remains the most effective strategy for optimizing long-term physical and mental performance.
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