This podcast episode focuses on diagnosing and treating diarrhea in various patient populations. The hosts discuss three cases: a child with acute viral gastroenteritis, a young adult with irritable bowel syndrome (IBS), and an older adult with *Clostridioides difficile* infection (CDI). Key diagnostic criteria for IBS (Rome IV criteria) and red flags indicating the need for further investigation are highlighted. The episode emphasizes the importance of proper hydration, particularly in children, and outlines treatment approaches including oral rehydration therapy (ORT) and antibiotic use for CDI, while cautioning against unnecessary antibiotic use in viral gastroenteritis. Listeners gain practical guidance on managing diarrhea cases based on patient age, symptoms, and risk factors.