This podcast delves into the diagnosis and treatment of dementia, highlighting how to distinguish it from delirium and depression. It covers essential topics such as recognizing early signs of cognitive decline, performing the necessary investigations—like lab tests and neuroimaging—using validated cognitive assessments, and differentiating Alzheimer's disease from other dementia types, including vascular dementia, Lewy body dementia, Parkinson's disease dementia, and frontotemporal dementia. The discussion underscores the significance of a comprehensive history and physical examination, along with gathering collateral information and considering various factors before reaching a diagnosis. Treatment options for Alzheimer's, such as cholinesterase inhibitors and memantine, are also explored. This engaging podcast is presented in two parts.