This podcast episode features an interview with Dr. Mike Israetel, an expert in exercise and sports science, who provides insights into evidence-based approaches for fat loss. The conversation covers topics such as the role of calories in fat loss, the importance of creating a net calorie deficit, the influence of the food environment on weight, the potential of modern pharmacology in treating obesity, the importance of food choices and meal timing, the significance of exercise and resistance training, and effective strategies for managing hunger and sticking to a diet. The episode emphasizes the importance of sustainable and long-term approaches to fat loss.