Continuous vs Intermittent β-Lactam Antibiotic Infusions in Patients With Sepsis

This JAMA Author Interviews podcast features Dr. Preeti Malani interviewing Drs. Joel Dulhunty and Jason Roberts about their related publications in JAMA regarding the use of continuous versus intermittent beta-lactam antibiotic infusions in critically ill patients with sepsis. Dr. Dulhunty discusses the BLING-3 randomized clinical trial, a large multinational study involving over 7,000 patients, which showed a possible benefit of continuous infusion, while Dr. Roberts details a systematic review and meta-analysis of 18 trials supporting the reduced mortality associated with prolonged infusions. Both discuss the practical implications and limitations of prolonged infusions, concluding that the evidence strongly suggests prolonged infusions should be considered a standard of care for sepsis treatment.