This podcast episode features an interview with Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, who discusses his work on epigenetic aging clocks. The conversation covers the development and implications of these clocks, including their ability to predict chronological age, healthspan, and lifespan. Dr. Horvath explains the differences between first and second-generation epigenetic clocks, highlighting the pan-tissue epigenetic clock and the PhenoAge and GrimAge clocks. The discussion touches on the influence of genetics, lifestyle factors, and specific conditions like cancer and Alzheimer's on epigenetic age. Additionally, the interview explores potential interventions for reversing epigenetic age, such as bone marrow transplants, Yamanaka factors, and lifestyle changes, while also addressing the challenges and limitations of using epigenetic clocks as clinical biomarkers.
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