This podcast episode analyzes premenstrual dysphoric disorder (PMDD), a severe reaction to hormonal changes during the menstrual cycle. It highlights the importance of understanding PMDD, its impact on mental health, and the need to address mental health stigma. It debunks common misconceptions, discusses treatment options, and explores the link between PMDD and suicidality. Furthermore, it emphasizes the significance of selecting hormone-sensitive samples when studying the menstrual cycle's effects on behavior.