#303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.
This podcast episode explores the science of longevity and focuses on clotho, a protein and gene related to Alzheimer's disease prevention. The conversation discusses the formation, mechanisms, and impact of clotho on brain health, as well as its potential for treating neurodegenerative diseases. The discovery of clotho and its role in longevity is also highlighted. The episode dives into the mechanism of action and cognitive enhancements of clotho, including its relationship with platelet factors. The podcast delves into the experiments conducted with clotho treatment in mouse models of Alzheimer's and Parkinson's diseases, showing promising results in enhancing cognition. The potential applications of clotho in human clinical trials and its implications for delaying the onset of neurodegenerative diseases are discussed. The conversation also addresses the importance of taking risks in scientific research and the dosing strategy for clotho treatment. The association between clotho, KLVS heterozygosity, and cognitive decline is explored, along with the significance of clotho levels in aging, disease outcomes, and organ health. The podcast concludes with discussions on the clotho test, KLVS polymorphisms, and the impact of exercise on clotho levels.
