This podcast episode explores the origins and persistence of the opioid epidemic, with a focus on the role of OxyContin, the influence of social spillovers, and the increasing presence of fentanyl in the drug market. The discussion highlights the need to understand the underlying factors driving the epidemic and emphasizes the importance of harm reduction and comprehensive addiction treatment. The episode also addresses the challenges of measuring drug use, the impact of globalized drug markets, and the potential drawbacks of decriminalization. Overall, the episode calls for a smarter approach to addressing the opioid crisis through prevention, effective regulation, and investment in youth.