This podcast episode focuses on infertility, providing a comprehensive guide for family physicians on diagnosing and managing cases. The hosts discuss a case study of a couple struggling to conceive, outlining a detailed history-taking approach using the mnemonic "STOP" (Sex & Semen, Tubes, Ovulation, Pelvis) and relevant physical exam considerations. They delve into investigations for infertility, including hormonal profiles, semen analysis, and ovarian reserve testing (AMH), emphasizing the importance of assessing both partners. The episode also covers common causes of infertility like PCOS and hyperprolactinemia, detailing their presentation, investigations, and management strategies. Finally, the hosts discuss treatment options, including lifestyle modifications, medication (e.g., metformin, letrozole), and assisted reproductive technologies, along with the importance of considering adoption.