This podcast episode explores the topic of unexplained weight loss and emphasizes the importance of investigating the underlying causes. It discusses the definition and significance of weight loss and categorizes the causes into three categories: decreased energy intake, increased energy expenditure, and increased nutrient loss. The episode provides a mnemonic, "Stop weight loss," to remember potential modifiable causes. It highlights the need for thorough history-taking, physical examination, and appropriate investigations by physicians. The episode also discusses the relationship between BMI and mortality in older adults and the significance of documenting patients' weight for accurate dosing and assessing growth milestones. It concludes by emphasizing the considerations for pharmacologic treatment of weight loss and the importance of addressing underlying issues.