Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

This podcast episode delves into the intricate workings of the brain's frontal lobes and prefrontal cortex, elucidating their pivotal roles in cognitive control, decision-making, and behavior regulation, while exploring the implications of frontal lobe damage and the impact of factors like technology and trauma on cognitive function.

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Andrew Huberman

Introduction and Overview of Executive Function

Exploring the Frontal Lobes and Prefrontal Cortex

Symptoms of Frontal Lobe Damage and Development

The Nature of Frontal Lobe Algorithms and Rules

Generalizability of Frontal Lobe Function and Cognitive Therapy

Connections Between the Prefrontal Cortex and Other Brain Regions

Connections Between the Prefrontal Cortex and the Body

The Impact of Smartphones and Social Media on Frontal Lobe Function

Introducing Working Memory and its Role in Cognition

Dopamine's Role in Working Memory and Its Circuitry

Assessing Dopamine Levels and the Inverted U-Shaped Function

Dopamine Agonists and Their Impact on Working Memory

Other Drugs for Enhancing Working Memory and the Importance of Cocktails

Neurological Biomarkers and Measuring Brain Health

The Impact of Traumatic Brain Injury (TBI) and Concussion

Advice for Patients with TBI and Concussion

The Role of Sleep, Exercise, and Cognitive Training in TBI Recovery

Brain Health, Neuroplasticity, and the "Use It or Lose It" Principle

The Need for a Brain Health Index and Optimizing Brain Function

Personal Practices for Optimizing Brain Function

The Importance of Human Interaction and Coaching for Brain Health

Understanding Alzheimer's Disease and its Genetic Link

Challenges in Treating Alzheimer's and Parkinson's

Approaches to Treating Early-Stage Alzheimer's and the Role of Hormones

Exercise and Mindfulness for Cognitive Function

Personal Experience with Mindfulness and the Need for Brain State Metrics

Brain Network Modularity and its Implications for Intervention

Shifting Focus from Nouns to Verbs in Neuroscience

Understanding Waking Brain States and the Need for Metrics

Psilocybin and Brain Network Connectivity

Combining Therapies for Cognitive Enhancement

Advocating for Brain Health and the Role of Patient Advocacy

Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Andrew Huberman

00:00Introduction and Overview of Executive Function

Introduction and Overview of Executive Function

07:01Exploring the Frontal Lobes and Prefrontal Cortex

Exploring the Frontal Lobes and Prefrontal Cortex

09:05Symptoms of Frontal Lobe Damage and Development

Symptoms of Frontal Lobe Damage and Development

14:26The Nature of Frontal Lobe Algorithms and Rules

The Nature of Frontal Lobe Algorithms and Rules

21:53Generalizability of Frontal Lobe Function and Cognitive Therapy

Generalizability of Frontal Lobe Function and Cognitive Therapy

26:05Connections Between the Prefrontal Cortex and Other Brain Regions

Connections Between the Prefrontal Cortex and Other Brain Regions

30:30Connections Between the Prefrontal Cortex and the Body

Connections Between the Prefrontal Cortex and the Body

39:43The Impact of Smartphones and Social Media on Frontal Lobe Function

The Impact of Smartphones and Social Media on Frontal Lobe Function

44:39Introducing Working Memory and its Role in Cognition

Introducing Working Memory and its Role in Cognition

47:56Dopamine's Role in Working Memory and Its Circuitry

Dopamine's Role in Working Memory and Its Circuitry

55:22Assessing Dopamine Levels and the Inverted U-Shaped Function

Assessing Dopamine Levels and the Inverted U-Shaped Function

1:00:05Dopamine Agonists and Their Impact on Working Memory

Dopamine Agonists and Their Impact on Working Memory

1:06:28Other Drugs for Enhancing Working Memory and the Importance of Cocktails

Other Drugs for Enhancing Working Memory and the Importance of Cocktails

1:09:38Neurological Biomarkers and Measuring Brain Health

Neurological Biomarkers and Measuring Brain Health

1:12:49The Impact of Traumatic Brain Injury (TBI) and Concussion

The Impact of Traumatic Brain Injury (TBI) and Concussion

1:22:51Advice for Patients with TBI and Concussion

Advice for Patients with TBI and Concussion

1:27:05The Role of Sleep, Exercise, and Cognitive Training in TBI Recovery

The Role of Sleep, Exercise, and Cognitive Training in TBI Recovery

1:32:20Brain Health, Neuroplasticity, and the "Use It or Lose It" Principle

Brain Health, Neuroplasticity, and the "Use It or Lose It" Principle

1:37:34The Need for a Brain Health Index and Optimizing Brain Function

The Need for a Brain Health Index and Optimizing Brain Function

1:40:04Personal Practices for Optimizing Brain Function

Personal Practices for Optimizing Brain Function

1:47:18The Importance of Human Interaction and Coaching for Brain Health

The Importance of Human Interaction and Coaching for Brain Health

1:52:47Understanding Alzheimer's Disease and its Genetic Link

Understanding Alzheimer's Disease and its Genetic Link

1:59:06Challenges in Treating Alzheimer's and Parkinson's

Challenges in Treating Alzheimer's and Parkinson's

2:01:00Approaches to Treating Early-Stage Alzheimer's and the Role of Hormones

Approaches to Treating Early-Stage Alzheimer's and the Role of Hormones

2:02:49Exercise and Mindfulness for Cognitive Function

Exercise and Mindfulness for Cognitive Function

2:08:25Personal Experience with Mindfulness and the Need for Brain State Metrics

Personal Experience with Mindfulness and the Need for Brain State Metrics

2:12:14Brain Network Modularity and its Implications for Intervention

Brain Network Modularity and its Implications for Intervention

2:17:14Shifting Focus from Nouns to Verbs in Neuroscience

Shifting Focus from Nouns to Verbs in Neuroscience

2:18:40Understanding Waking Brain States and the Need for Metrics

Understanding Waking Brain States and the Need for Metrics

2:22:41Psilocybin and Brain Network Connectivity

Psilocybin and Brain Network Connectivity

2:25:32Combining Therapies for Cognitive Enhancement

Combining Therapies for Cognitive Enhancement

2:29:26Advocating for Brain Health and the Role of Patient Advocacy

Advocating for Brain Health and the Role of Patient Advocacy