This podcast episode explores the principles of pioneering and risk management in the field of biotech venture capital. The CEO partner of Flagship Pioneering, Margo Georgiadis, shares her diverse leadership experiences and discusses the importance of courage, conviction, and thinking differently. The episode emphasizes the need to venture into uncharted territories, embrace uncertainty, and create value by addressing higher uncertainty. The process of building deep tech ventures and the significance of diversity in leadership are also discussed. The speakers highlight the importance of finding the "why now" in business opportunities and managing risk through strategic decision-making. The challenges of scaling platforms and navigating uncertain industries are explored, as well as the opportunities and challenges in the field of drug discovery and the role of AI. The episode concludes by emphasizing the importance of making healthcare accessible and affordable and addressing the challenges of obtaining funding and amassing knowledge.