#193: My Life Extension Pilgrimage to Easter Island

This podcast episode delves into the fascinating journey of rapamycin from its origins in the soil of Easter Island to its FDA approval and potential applications in extending lifespan and healthspan, with insights from experts Peter Attia, David Sabatini, and Navdeep Chandel. They discuss the intricate relationship between rapamycin and mTOR, the importance of balancing lifespan with healthspan, and the need for scientific rigor in aging research, all underscored by personal experiences and anecdotes that highlight the challenges and promises of longevity interventions.

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The Tim Ferriss Show

Life Extension Pilgrimage: Introducing the Experts

The Rapamycin Story: From Easter Island to FDA Approval

David Sabatini's Journey with Rapamycin: From Control Drug to Lifespan Research

The Birdman Competition: A Test of Strength and Endurance

Rapamycin's Potential Applications: From Organ Transplants to Lifespan Extension

Healthspan vs. Lifespan: The Importance of Quality of Life

Intermittent Dosing of Rapamycin: Mimicking Fasting and Autophagy

Rapamycin vs. Metformin: Two Promising Drugs for Longevity

The Science Behind Metformin: A Multifaceted Drug with Uncertain Mechanisms

The Case Against Antioxidants: Challenging Conventional Wisdom

The Importance of Understanding Asymmetric Risk: When to Take a Risk and When Not To

Navdeep Chandel's Journey: From Math to Metabolism

The Importance of Confidence and Failure: Lessons for Life and Science

The Ask Crack Rating System: A Unique Approach to Data Aesthetics

Fonts, Spacing, and the Pursuit of Perfection: A Look at Peter Attia's Obsession

The Decision to Avoid Glasses: A Fear of Dependence

The Calculus of Intervention: When to Take a Compound and When Not To

The Quest for Longevity: A Balancing Act of Risk and Reward

The Power of Books: Insights from Navdeep Chandel and David Sabatini

The Ideal Billboard: A Reflection of Values and Aspirations

The Power of Mutual Benefit: A Philosophy for Relationships

The Power of Friendship: A Shared Appreciation for Openness and Honesty

Advice to Younger Selves: Reflections on Relationships and Priorities

The Importance of Efficiency: A Life Hack from Navdeep Chandel

The Decision to Pursue Research: A Moral Conundrum and a Life-Changing Choice

The Legacy of Rapamycin: A Tribute to Soren Sehgal and a Call for Further Research

Finding the Experts: Contact Information and a Call for Collaboration

A Call for Skepticism and Scientific Rigor: The Importance of Critical Thinking

The Future of Longevity Research: A Call for Innovation and Collaboration

#193: My Life Extension Pilgrimage to Easter Island

The Tim Ferriss Show

00:05Life Extension Pilgrimage: Introducing the Experts

Life Extension Pilgrimage: Introducing the Experts

08:11The Rapamycin Story: From Easter Island to FDA Approval

The Rapamycin Story: From Easter Island to FDA Approval

18:51David Sabatini's Journey with Rapamycin: From Control Drug to Lifespan Research

David Sabatini's Journey with Rapamycin: From Control Drug to Lifespan Research

27:15The Birdman Competition: A Test of Strength and Endurance

The Birdman Competition: A Test of Strength and Endurance

31:21Rapamycin's Potential Applications: From Organ Transplants to Lifespan Extension

Rapamycin's Potential Applications: From Organ Transplants to Lifespan Extension

36:17Healthspan vs. Lifespan: The Importance of Quality of Life

Healthspan vs. Lifespan: The Importance of Quality of Life

44:26Intermittent Dosing of Rapamycin: Mimicking Fasting and Autophagy

Intermittent Dosing of Rapamycin: Mimicking Fasting and Autophagy

50:00Rapamycin vs. Metformin: Two Promising Drugs for Longevity

Rapamycin vs. Metformin: Two Promising Drugs for Longevity

1:01:13The Science Behind Metformin: A Multifaceted Drug with Uncertain Mechanisms

The Science Behind Metformin: A Multifaceted Drug with Uncertain Mechanisms

1:12:34The Case Against Antioxidants: Challenging Conventional Wisdom

The Case Against Antioxidants: Challenging Conventional Wisdom

1:18:24The Importance of Understanding Asymmetric Risk: When to Take a Risk and When Not To

The Importance of Understanding Asymmetric Risk: When to Take a Risk and When Not To

1:26:28Navdeep Chandel's Journey: From Math to Metabolism

Navdeep Chandel's Journey: From Math to Metabolism

1:33:01The Importance of Confidence and Failure: Lessons for Life and Science

The Importance of Confidence and Failure: Lessons for Life and Science

1:41:02The Ask Crack Rating System: A Unique Approach to Data Aesthetics

The Ask Crack Rating System: A Unique Approach to Data Aesthetics

1:47:02Fonts, Spacing, and the Pursuit of Perfection: A Look at Peter Attia's Obsession

Fonts, Spacing, and the Pursuit of Perfection: A Look at Peter Attia's Obsession

1:50:51The Decision to Avoid Glasses: A Fear of Dependence

The Decision to Avoid Glasses: A Fear of Dependence

1:56:07The Calculus of Intervention: When to Take a Compound and When Not To

The Calculus of Intervention: When to Take a Compound and When Not To

2:00:01The Quest for Longevity: A Balancing Act of Risk and Reward

The Quest for Longevity: A Balancing Act of Risk and Reward

2:08:00The Power of Books: Insights from Navdeep Chandel and David Sabatini

The Power of Books: Insights from Navdeep Chandel and David Sabatini

2:11:56The Ideal Billboard: A Reflection of Values and Aspirations

The Ideal Billboard: A Reflection of Values and Aspirations

2:16:01The Power of Mutual Benefit: A Philosophy for Relationships

The Power of Mutual Benefit: A Philosophy for Relationships

2:23:55The Power of Friendship: A Shared Appreciation for Openness and Honesty

The Power of Friendship: A Shared Appreciation for Openness and Honesty

2:33:15Advice to Younger Selves: Reflections on Relationships and Priorities

Advice to Younger Selves: Reflections on Relationships and Priorities

2:40:00The Importance of Efficiency: A Life Hack from Navdeep Chandel

The Importance of Efficiency: A Life Hack from Navdeep Chandel

2:47:25The Decision to Pursue Research: A Moral Conundrum and a Life-Changing Choice

The Decision to Pursue Research: A Moral Conundrum and a Life-Changing Choice

2:52:32The Legacy of Rapamycin: A Tribute to Soren Sehgal and a Call for Further Research

The Legacy of Rapamycin: A Tribute to Soren Sehgal and a Call for Further Research

2:58:09Finding the Experts: Contact Information and a Call for Collaboration

Finding the Experts: Contact Information and a Call for Collaboration

3:01:36A Call for Skepticism and Scientific Rigor: The Importance of Critical Thinking

A Call for Skepticism and Scientific Rigor: The Importance of Critical Thinking

3:03:57The Future of Longevity Research: A Call for Innovation and Collaboration

The Future of Longevity Research: A Call for Innovation and Collaboration