This podcast episode explores the quality of research on gender-affirming care, particularly in the context of studies on young people. The episode discusses the challenges in evaluating research quality, the origin of a claim regarding the exclusion of research, and the nuances of interpreting systematic reviews. It emphasizes the need for high-quality studies that account for differences between groups, have long-term follow-up, and provide representative data. The episode also highlights the importance of understanding systematic reviews and the challenges of communicating complex research findings to the public.