This podcast episode explores the topics of longevity science, myths and misconceptions about aging, key biomarkers of aging, potential strategies for slowing the aging process, and the impact of lifestyle factors on longevity. The speakers discuss various aspects of healthy aging, including the importance of maintaining skeletal muscle mass and function, the complexities of calorie restriction and protein intake, the potential benefits of supplementation with nicotinamide riboside (NR), and the effects of alcohol and nicotine on the NAD system. They also explore the role of biomarkers and functional tests in assessing aging, as well as the potential drawbacks of testosterone replacement therapy (TRT) for longevity. Overall, the episode emphasizes the need for a balanced approach to maintaining health and well-being as we age.